Uncompromising cryopreservation 

PentaHibe used as sole cryoprotective agent (CPA), either completely avoiding the use of DMSO or mixed with minimum concentrations of DMSO — depending on the cell type — demonstrates high recovery and viability and specifically higher recovery rates than cryopreservation solutions using 10% DMSO.

PentaHibe with no or minimum concentrations of DMSO has been tested on hematopoietic stem cells, human mesenchymal stem cells (hMSC), T cells and CHO cells, consistently demonstrating comparable or improved functionality.

The non-toxic nature of pentaisomaltose — our patented non-permeating cryoprotective agent which breaks down into glucose and water in the body — is supported by expert toxicity report in both humans and various animal species. This positions PentaHibe as a less toxic alternative for cryopreservation, opening up its potential for broader clinical applications in cell therapies.

PentaHibe is biocompatible, sterile, free of animal components, and low endotoxin. This enhances experimental integrity, supports consistent and reliable results while meeting safety and quality standards.

PentaHibe is well-tolerated in humans, degrading into glucose and water in the body. It is rapidly and completely excreted via glomerular filtration, producing no harmful metabolites — unlike DMSO.

PentaHibe reduces or eliminates the need for DMSO to just 1-2%, significantly decreasing DMSO toxicity-related issues such as "cellular toxicity, alterations in cellular epigenetic states, and patient-related side effects, including cardiac or respiratory arrest, neurotoxicity, and epileptic seizures.1"

PentaHibe is supported by all the quality assurance documentation you need for regulatory approval, such as batch certifications, stability studies, expert toxicity report, and US Drug Master files (DMF).

PentaHibe is manufactured according to the highest quality standards in a cGMP manufacturing facility to assure proper design, monitoring, and control of manufacturing processes and facilities. Additionally, Pharmacosmos carbohydrates are incorporated into several FDA-approved small-molecule drugs and biologics.

With PentaHibe, you have the documented quality you need to smoothly transition from research and development to clinical testing and full-scale manufacturing. We have the ability to deliver quantities ranging from 1 gram to tons.