Resources

Supporting you from research to production

In this section, you can download protocols to support implementation in your workflow, along with publications and white papers to explore the underlying data in greater depth.

Need more documentation? We provide comprehensive regulatory support, including toxicology reports, documentation for regulatory submissions, a US Drug Master File (DMF), and GMP compliance certificates — all available upon request.

Publications
Ref 1: Svalgaard JD et al. Cell Transplantation, 2018 Sept; Vol 27(9): 1407-1412
Pentaisomaltose, An Alternative To DMSO. Engraftment Of Cryopreserved Human CD34+ Cells In Immunodeficient NSG Mice
Ref 2: Svalgaard JD et al. Transplantation and Cellular Engineering, 2016 May; Vol 56(5): 1088-1095
Low Molecular Weight Carbohydrate Pentaisomaltose May Replace Dimethyl Sulfoxide As A Safer Cryoprotectant For Cryopreservation Of Peripheral Blood Stem Cells
Ref 4: Haastrup EK et al. Transplantation and Apheresis Science, 2021; Vol 60(4): 103138
DMSO (Me2SO) Concentrations Of 1-2% In Combination With Pentaisomaltose Are Effective For Cryopreservation Of T Cells
Ref 5: Svalgaard JD et al. Cryobiology, 2020; Vol 96(01): 207-213
Cryopreservation Of Adipose Derived Stromal/Stem Cells Using 1–2% Me2SO (DMSO) In Combination With Pentaisomaltose: An Effective And Less Toxic Alternative To Comparable Freezing Media
Ref 8: Hamann A et al. Application Note, 2025 August
Superior Cryopreservation of T Cells in Low-DMSO, Animal-Origin-Free Formulation Using Optibumin 25 and PentaHibe® Base
Protocols
Cryopreservation protocol using Pentahibe® Complete
Protocol for DMSO-free cryopreservation of HPC(A) products
Protocol for DMSO-reduced cryopreservation using 10% Pentahibe® Base, 2% DMSO and 4% albumin
Protocol for cryopreservation of gut biopsies using Pentahibe® Complete
White Papers
Preserving Functional Performance of Human T Cells with PentaHibe® Complete
Optimizing Cryopreservation Performance in T-Cell Therapy Workflows
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