Research and publications

Ensure viability, enhance functionality, and maintain consistency

Explore the data on PentaHibe Base and PentaHibe Complete tested on different cell types for viability, recovery and proliferation.
Deep dive into the publications and download our protocols for guidance.


A ready-to-use cryopreservation medium containing 10% pentaisomaltose and 2% DMSO, PentaHibe Complete can be used with a range of cell types.

For cell-based therapies
For other cell lines


A natural carbohydrate-based cryoprotective agent, PentaHibe Base is a safe and effective alternative to dimethyl sulfoxide (DMSO) for cryopreservation of cells.

When used as sole cryoprotective agent
For custom-made formulations
Ref 1: Svalgaard JD et al. Cell Transplantation, 2018 Sept; Vol 27(9): 1407-1412
Pentaisomaltose, An Alternative To DMSO. Engraftment Of Cryopreserved Human CD34+ Cells In Immunodeficient NSG Mice
Ref 2: Svalgaard JD et al. Transplantation and Cellular Engineering, 2016 May; Vol 56(5): 1088-1095
Low Molecular Weight Carbohydrate Pentaisomaltose May Replace Dimethyl Sulfoxide As A Safer Cryoprotectant For Cryopreservation Of Peripheral Blood Stem Cells
Ref 4: Haastrup EK et al. Transplantation and Apheresis Science, 2021; Vol 60(4): 103138
DMSO (Me2SO) Concentrations Of 1-2% In Combination With Pentaisomaltose Are Effective For Cryopreservation Of T Cells
Ref 5: Svalgaard JD et al. Cryobiology, 2020; Vol 96(01): 207-213
Cryopreservation Of Adipose Derived Stromal/Stem Cells Using 1–2% Me2SO (DMSO) In Combination With Pentaisomaltose: An Effective And Less Toxic Alternative To Comparable Freezing Media
Cryopreservation protocol using Pentahibe Complete
Protocol for DMSO-free cryopreservation of HPC(A) products
Protocol for DMSO-reduced cryopreservation using 10% Pentahibe Base, 2% DMSO and 4% albumin
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